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The following terms were not found in PubMed: 0618600ORrhomboid, ROM10ANDPlasmodium
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Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children.
PLoS One. 2014 Aug 21;9(8):e105690. doi: 10.1371/journal.pone.0105690. eCollection 2014.
PLoS One. 2014.
PMID: 25144768
Free PMC article.
Clinical Trial.
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) encoding kelch (K13) propeller domains, providing a molecular marker to monitor the spread of resistance. The P. falciparum cysteine …
Recently, the artemisinin resistance phenotype was attributed to mutations in portions of a P. falciparum gene (PF3D7_1343700) …
Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation.
Calic PPS, Vinh NB, Webb CT, Malcolm TR, Ngo A, Lowes K, Drinkwater N, McGowan S, Scammells PJ.
Calic PPS, et al.
Eur J Med Chem. 2023 Feb 15;248:115051. doi: 10.1016/j.ejmech.2022.115051. Epub 2022 Dec 29.
Eur J Med Chem. 2023.
PMID: 36634455
Previously identified novel hydroxamic acid 2 as a moderate inhibitor of PfA-M1 and PfA-M17 and a potent inhibitor of P. falciparum. This study has sought to improve the enzymatic inhibitory properties in addition to increasing the drug-likeness of this scaffold by introdu …
Previously identified novel hydroxamic acid 2 as a moderate inhibitor of PfA-M1 and PfA-M17 and a potent inhibitor of P. falciparum. …
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